Aging is the predominant risk factor for cardiovascular disease (1) and contributes to a significantly worse outcome in patients with acute myocardial infarction (2). This risk is partly attributable to an age-related decline in the ability of vascular cells to resist stress and effectively remodel the arterial wall. Vascular smooth muscle cells are particularly important in this regard. Strategies to prevent premature senescence of vascular smooth muscle cells could provide an effective approach to reduce vascular diseases. Over the past decade, dietary supplementation with resveratrol (3,5,4´-trihydroxystilbene), a plant-derived polyphenol, has emerged as a promising approach to counteract age-induced pro-atherogenic phenotypic changes. in the vascular system. Resveratrol has been shown to exert significant anti-aging action in vertebrates (3). The gene expression patterns induced by resveratrol resembled those induced by calorie restriction (CR) and delayed aging-related deterioration (4). Resveratrol and CR both have beneficial effects in various mammalian models of aging and aging....