Tissue engineering is a field that involves biology, medicine and engineering. It aims to restore, maintain and improve the function of tissues and organs by implanting natural, synthetic or semi-synthetic tissues and bioartificial organs that are fully functional from the start or that achieve the required functionality (Nature Publishing Group., 2014 ). It appears as a potential alternative or complementary solution to organ failure. Basic principles of tissue engineering (Castells-Sala, et al., 2013). A concrete example of its application in the human body is wound repair. Tissue engineering is mainly focused in this application on artificial skin to treat burns, but it can also be used in various other skin diseases. An example of this is the Advanced Tissue Sciences Dermagraft, which is a three-dimensional culture of human neonatal dermal fibroblasts that has been grown on a biodegradable scaffold and has been cryopreserved (Nature Publishing Group., 2014). The main function of a scaffold is to direct cellular behavior such as migration, proliferation, differentiation, and phenotype maintenance (Amoabediny, Salehi-Nik, & Heli, 2011). The use of this Dermagraft is intended for the treatment of foot ulcers that have developed as a side effect of long-term diabetes. According to clinical trials, significant healing occurred with this material, particularly when the cells in the Dermagraft were alive and fully functional. The way Dermagraft works is that it is placed over the ulcer and the mesh material gradually seeps into the skin where the human cells. fall into place and replace the damaged skin. The living cells in Dermagraft produce many of the same proteins and growth factors found in healthy skin... middle of article...... engineering/regenerative medicine number. Retrieved April 5, 2014, from Tissue Engineering Pages: http://www.tissue-engineering.net/index.php?seite=whatisteWebMD. (December 14, 2012). WebMD. Retrieved April 27, 2014 from Central Venous Catheters: http://www.webmd.com/pain-management/tc/central-venous-catheters-topic-overview Wendt, D., Timmins, N., Malda, J., Janssen , F., Ratcliffe, A., Vunjak-Novakovic, G., et al. (2008). Chapter 16: Bioreactors for tissue engineering. In C. van Blitterswijk, P. Thomsen, A. Lindahl, J. Hubbel, DF Williams, R. Cancedda et al., Tissue Engineering (pp. 484-488). Elsevier Inc. Yannas, IV (August 15, 2000). pnas.org. Retrieved April 27, 2014 from PNAS: www.pnas.orgZielinski, B. and Lysaght, M. (2007). Chapter 28: Immunoisolation. In R. Lanza, R. Langer, and J. Vacanti, Principles of tissue engineering (p. 399). Elsevier Inc..