The objectives of this study were to measure the physicochemical properties of miconazole nitrate (MCZ: one brand name (MCZ-A) and three generics (MCZ-B, -C and - D)) creams, to carry out human sensory tests of these creams. The flattening, viscoelasticity, and water content of each cream were measured, and each cream was subjected to near-infrared (NIR) absorption spectroscopy and sensory testing. The elasticity value was calculated based on the measured kurtosis and was 734.8 dynes/cm2 for MCZ-A, 1198.9 dynes/cm2 for MCZ-B, 461.3 dynes/cm2 for MCZ -C and 3,112.3 dynes/cm2 for MCZ-D. Measurement of viscoelasticity and viscosity revealed that MCZ-C had a smaller tanδ than the other 3 creams at 25°C. NIR absorption spectroscopy revealed that MCZ-A showed the highest absorption peak due to hydroxyl groups, followed by MCZ-C, -B, and then -D. Water content measurement revealed that MCZ-A had a water content of 65.9%, MCZ-B, -C and -D had a water content of approximately 56.3%. Human sensory testing revealed differences between MCZ-A and MCZ-C and between MCZ-B and MCZ-D in terms of spread and sensation. These results indicate that differences in water and oil content and emulsification gave the creams different physical properties, such as flattening, internal structure, and dynamic viscoelasticity. NIR absorption spectroscopy, which allows the non-destructive measurement of the physicochemical properties of a sample, and viscoelasticity and viscosity measurement, which allows the dynamic viscoelasticity of a sample to be measured, have revealed differences in the physical properties of creams.Keywords: miconazole, spreadability, near infrared, sensory testing, physicochemical propertiesIntroductionProviding safe and effective medicines to every patient...... middle of paper ......viscosity in particular is a important element of the association between physicochemical properties and touch. Additionally, creams are made primarily from additives, so a preparation can be greatly affected by additives. In studies on ACV and TA, this laboratory compared preparations containing different additives. However, no studies have compared the characteristics of preparations with the same types of additives, and no studies have examined physical properties and feel. The present study evaluated the physicochemical properties of MCZ creams with the same additives. The creams were also compared in human sensory tests. As reported here, the results provided information for selecting a preparation in accordance with patient preference and prescribing physician intent without first requiring use of the preparation in a clinical setting..