IntroductionDisease!!!!! Disease!!!! Disease!!!! Living on this earth, we are exposed to many different infectious diseases. Hepatitis E is a very serious liver disease caused by the hepatitis E virus (HEV) that usually results in an acute infection. (http://www.cdc.gov/hepatitis). It is safe to say that hepatitis E does not lead to chronic infection according to the CDC. In this research paper, I will identify the causative agent, geographic distribution, transmission, clinical features, diagnosis, treatment and control measures of this serious liver disease. Key facts about hepatitis E may include: • Each year, there are 20 million hepatitis E infections, more than 3 million acute cases of hepatitis E, and 57,000 hepatitis E-related deaths .• Hepatitis E occurs worldwide, but prevalence is highest in East and South Asia• Hepatitis E is usually self-limiting, but can progress to fulminant hepatitis and is transmitted through fecal-oral, mainly through contaminated water.• China produced and authorized the first vaccine to prevent hepatitis E virus infection, although it is not yet available. available worldwide.The causative agentThe causative agent of hepatitis E is the hepatitis E virus (HEV). According to my research, the virus came from the stool of an orally infected volunteer with faces from suspected cases of non-A and non-B hepatitis (Balayan et al. 1983). The hepatitis E virus is a unique, positive-sense, undeveloped virus. The stranded ribonucleic acid (RNA) virus is approximately 27 to 30 nm (veterinami medicina 52, 2007) (HEV). Infections are spread by the fecal-oral route and cause acute, sporadic, and epidemic viral hepatitis worldwide, usually through contaminated water supplies. . (Vasickova et al., 200...... middle of article ......s first observed and described in 1983 (Balayan et al., 1983). The virus was the subject extensive study since then. Eventually, to assign this virus to a taxonomic class, the virus was classified in the genus Hepevirus, family Hepeviridae in 2004 (Emerson et al., 2004; http://www. ncbi.nlm.nih.gov/ICTVdb/Ictv/fs_hepev.htm).Anti-HEV (or viral RNA) antibodies have not only been found in humans, but also detected in various animal species (Arankalle et al., 1994, 2001; Favorov et al., 1998).Bibliography (http://www.ncbi.nlm.nih.gov/ICTVdb/Ictv/fs_hepev.htm).Who.int/Hepatitis E1 http://www.cdc .gov/hepatitis/HEV/HEVfaq.htm2.http: //www.who.int/mediacentre/factsheets/fs280/en/3 http://www.rightdiagnosis.com/h/hepatitis_e/intro.htm4 52- 9-365.pdf5. http://hepatitis.emedtv.com/hepatitis-e/hepatitis-e.html