Objectives: Triphala is the combination of three medicinal plants, widely used in Ayurveda since Antiquity. Triphala mouthwash is used in the treatment of periodontal disease due to its antimicrobial and antioxidant properties. The aim of this study is to compare the effectiveness of Triphala mouthwash with 0.2% chlorhexidine in hospitalized patients with periodontal disease. Material and method: In this randomized, multicenter, double-blind clinical trial, 120 patients were divided equally into three groups. Patients in group A were advised to rinse their mouth with 10 ml of distilled water, group B with 0.2% chlorhexidine and group C with triphala mouthwash for one minute twice a day. day for two weeks. Plaque index (PI) and gingival index (GI) were recorded on the first and fifteenth days. Results: There was no significant difference when the effectiveness of triphala was compared with that of chlorhexidine 0.2% in hospitalized patients with periodontal disease. However, a statistically significant difference was observed in PI and GI when group B and group C were compared with group A as well as within groups B and C, after 15 days (p < 0, 05). Conclusion: Triphala mouthwash (herbal) is an effective means. antiplaque agent such as chlorhexidine 0.2%. It is very useful in reducing the accumulation of dental plaque and gingival inflammation, thus controlling periodontal diseases in each patient. It is also cost-effective, readily available, and well-tolerated, with no reported side effects. Key words: triphala, chlorhexidine, gingivitis, periodontitis, dental plaque control. Periodontal disease appears to occur when a pathogenic microbial plaque acts on a susceptible host[1]. Control of supragingival plaque is fundamental for the prevention and management of peri...... middle of paper ...... problems such as bleeding gums, halitosis, oral ulcers and prevention dental caries. The main strength of these natural herbs is that their use has not resulted in any side effects till date [21]. According to SushrutaSamhita in his 20thshloka, Triphala can be used as a gargling agent in dental diseases. Abraham et al, [22] indicated the strong inhibitory activity of triphala against PMN-type collagenases, including MMP-9 and confirmed the use of triphala in periodontal diseases. It has antimicrobial, antiseptic, anti-inflammatory and antioxidant properties as well as many other properties [16-17, 23-27]. Due to the numerous properties of triphala as well as its other advantages such as ease of availability and cost effectiveness, the present study was undertaken to verify its effectiveness with commercially available CHX in hospitalized patients with periodontal disease..